Let’s face it—a night out in Singapore doesn’t always end with just one drink. Whether you’re sipping cocktails at Atlas or knocking back shots at Zouk, you might also be popping a few supplements to stay on top of your health game. But here’s the kicker: some supplements and alcohol just don’t mix. In fact, combining the wrong vitamins or herbal ingredients with alcohol can actually do more harm than good.
That’s right. While you’re out trying to party smart, you could be accidentally doubling your hangover—or worse, putting your liver at risk.
So, what should savvy drinkers in Singapore be avoiding? Here's what the research really says.
1. Niacin (Vitamin B3)
Why it matters: Niacin is often marketed as a detox aid or energy booster. But taken in high doses, it can be toxic to the liver—especially when alcohol is involved.
The science: A case study published on the National Center for Biotechnology Information describes how sustained-release niacin (around 4.5g/day) caused jaundice and elevated liver enzymes in a healthy adult. The liver damage reversed once the supplement was stopped.
Our advice: Avoid high doses of niacin when drinking. You might think you're helping your liver, but you could be stressing it out even more.
2. Pyridoxine (Vitamin B6)
Why it matters: B6 is crucial for brain and nerve health. But too much of it? That can backfire.
The science: The Guardian reported a case where an Australian man developed nerve damage due to taking multivitamins with extremely high B6 content. Alcohol can amplify this risk, given its own neurotoxic effects.
Our advice: Stick to low or recommended daily intake levels. If your supplement stack is already B6-heavy, consider skipping it on drinking days.
3. Vitamin E
Why it matters: Vitamin E is an antioxidant, often associated with skin and immune benefits. But it also acts as a natural blood thinner.
The science: EatingWell warns that high doses of vitamin E can increase the risk of bleeding. When alcohol—another blood thinner—enters the mix, the effects may compound.
Our advice: If you're supplementing with vitamin E, keep it moderate and skip it before a night out.
4. Choline
Why it matters: Choline supports liver function and cognitive health. Sounds like a win, right? But too much may be too much.
The science: According to a 2024 study, excess choline supplementation may exacerbate liver fibrosis under certain conditions. And while moderate levels are beneficial, piling on choline while drinking could stress the liver further.
Our advice: Don’t overdo it. Aim for balance. Choline isn’t bad—just don’t megadose it around your drinking sessions.
5. Ginseng
Why it matters: Ginseng is a popular adaptogen found in many anti-hangover supplements, especially those sold in Singapore. But it might not be as harmless as it seems.
The science: While it has many benefits, ginseng also affects liver enzymes (especially the cytochrome P450 family) responsible for metabolizing alcohol and various medications (NIH source).
- This interference can increase the risk of liver stress or drug interactions, especially with heavy drinking or if you’re on medications.
- Due to this enzyme modulation, combining ginseng supplements with alcohol may not be the safest choice.
Our advice: Avoid ginseng supplements on drinking days to reduce the risk of liver overload and complications.
So, What Should You Take Instead?
Instead of overloading your system with the wrong stuff, choose a supplement that supports your body’s natural detox and recovery processes—without the baggage.
Locohol is formulated with:
- S-Acetyl Glutathione — A powerful antioxidant that protects your liver.
- DHM (from Japanese Raisin Tree) — Backed by studies for its role in promoting alcohol breakdown.
- Turmeric and Ginger — Known for its anti-inflammatory and liver-supportive benefits.
- Magnesium Glycinate — Supports nervous system function and can improve sleep quality after drinking.
None of the questionable extras. Just clean, clinically-backed ingredients that work with your body—not against it.
Final Thoughts
In Singapore’s fast-paced social scene, taking care of your body while enjoying a night out is smart—but you’ve got to do it right. Not all supplements are created equal, and some could be silently sabotaging your liver while you party.
If you’re a frequent drinker looking for the best anti-hangover pill supplement in Singapore, go with something designed for both effectiveness and safety.
Your body (and your Sunday morning) will thank you.